Loxistatin Acid

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Loxistatin Acid (E-64C) 是 E-64 的衍生物，是一种不可逆的膜渗透性半胱氨酸蛋白酶抑制剂。

Loxistatin Acid (E-64C), a derivative of E-64, is an irreversible and membrane-permeant cysteine protease inhibitor.

E-64c, a derivative of naturally occurring epoxide inhibitor of cysteine proteases, with papain; especially with regard to the hydrogen bonding and hydrophobic interactions of the ligands with conserved residues in the catalytic binding site. E 64c (k2/Ki=140±5M-1s-1) is demonstrated to be a lead structure for the development of irreversible cathepsin C inhibitors.

The t-1/2 of plasma E-64c is 0.48 hours. The hemodynamic effects of E-64c are absent at this dose. Using two way analysis of variance, the effects of reperfusion (p=0.0016) or E-64c (p=0.0226) per se on infarct size are significant. In comparing Group A with Group B and Group C with Group D, the depletion of CPK in the E-64c treated groups (Groups A and C) is slightly less than in the vehicle-injected groups (Groups B and D). The insufficient effect of E-64c alone may be explained by the early administration and relatively short t-1/2. Since the effectiveness of NCO-700 has been established,6),7) our findings might indicate a small but beneficial effect of E-64c on infarct size and CPK content.

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Endocrinology/Hormones

RAAS

Cysteine protease

Others-Field

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76684-89-4

314.38

C15H26N2O5

>98% (HPLC)

In Vitro:?DMSO : 250 mg/mL (795.22 mM)

CC(C)CCNC(=O)[C@H](CC(C)C)NC(=O)[C@H]1O[C@@H]1C(O)=O

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(-20℃)

With Ice Pack

≥ 2 years